UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Cranial bone structure in children with sagittal craniosynostosis: relationship with surgical outcomes

Rodriguez-Florez, N; Ibrahim, A; Hutchinson, JC; Borghi, A; James, G; Arthurs, O; Ferretti, P; ... Jeelani, NUO; + view all (2017) Cranial bone structure in children with sagittal craniosynostosis: relationship with surgical outcomes. Journal of Plastic, Reconstructive & Aesthetic Surgery , 70 (11) pp. 1589-1597. 10.1016/j.bjps.2017.06.017. Green open access

[img]
Preview
Text
Rodriguez Florez_1-s2.0-S1748681517302632-main.pdf - ["content_typename_Published version" not defined]

Download (1MB) | Preview

Abstract

BACKGROUND: Whilst spring-assisted cranioplasty has become a widespread technique to correct scaphocephaly in children with sagittal synostosis, predicting head shape changes induced by the gradual opening of the springs remains challenging. The aim of this study was to explore the role of cranial bone structure on surgical outcomes. METHODS: Patients with isolated sagittal synostosis undergoing spring-assisted cranioplasty at GOSH (London, UK) were recruited (n=18, age: 3-8 months). Surgical outcome was assessed by the change in cephalic index measured on 3D head scans acquired before spring insertion and after their removal using a 3D handheld scanner. Parietal bone samples routinely discarded during spring-assisted cranioplasty were collected and scanned using micro-computed tomography. Based upon visual assessment of such scans, bone structure was classified into one- or three-layered, the latter indicating the existence of a diploё cavity. Bone average thickness, volume fraction and surface density were computed and correlated with changes in cephalic index. RESULTS: Cephalic index increased for all patients (p<0.001), but individual improvement varied. While the patient age and treatment duration were not significantly correlated with changes in cephalic index, bone structural parameters were. The increase of cephalic index was smaller with increasing bone thickness (Pearson’s r =-0.79, p<0.001) and decreasing bone surface density (r=0.77, p<0.001), associated with the three-layered bone structure. CONCLUSIONS: Variation in parietal bone micro-structure was associated with the magnitude of head shape changes induced by spring-assisted cranioplasty. This suggests that bone structure analysis could be a valuable adjunct in designing surgical strategies that yield optimal patient-specific outcomes.

Type: Article
Title: Cranial bone structure in children with sagittal craniosynostosis: relationship with surgical outcomes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bjps.2017.06.017
Publisher version: https://doi.org/10.1016/j.bjps.2017.06.017
Language: English
Additional information: Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: cranial bone; Craniosynostosis; Spring-Assisted Cranioplasty; micro-CT; 3D scanning
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Children's Cardiovascular Disease
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Development Bio and Cancer Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1563695
Downloads since deposit
44Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item