Mustapa, MFM and Harris, R and Esposito, D and Chubb, NAL and Mould, J and Schultz, D and Driscoll, PC and Tabor, AB (2003) Synthesis of a cyclic peptide containing norlanthionine: Effect of the thioether bridge on peptide conformation. J ORG CHEM , 68 (21) 8193 - 8198. 10.1021/jo0346407.
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Abstract
Two diastereomeric analogues of ring C of nisin incorporating a novel norlanthionine residue have been synthesized via a triply orthogonal protecting group strategy. A full structural study was carried out by NMR, which elucidated the conformational properties of the two peptides and enabled the identity of each diastereoisomer to be proposed.
| Type: | Article |
|---|---|
| Title: | Synthesis of a cyclic peptide containing norlanthionine: Effect of the thioether bridge on peptide conformation |
| DOI: | 10.1021/jo0346407 |
| Keywords: | SOLID-PHASE SYNTHESIS, LANTIBIOTIC NISIN, BIOLOGICAL-ACTIVITIES, NMR-SPECTROSCOPY, QUANTUM NMR, LANTHIONINE, VANCOMYCIN, DESIGN, BIOSYNTHESIS, CYCLIZATION |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
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