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Undecaprenyl diphosphate synthase reaction with artificial substrate homologues - novel behavior in the termination of prenyl chain elongation

(1989) Undecaprenyl diphosphate synthase reaction with artificial substrate homologues - novel behavior in the termination of prenyl chain elongation. Tetrahedron , 45 (19) pp. 6145-6160. 10.1016/S0040-4020(01)85127-9.

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Abstract

(E)-3-Methyl-3-pentenyl diphosphate acted as an artificial homoallylic substrate in the reaction with several allylic diphosphates catalyzed by undecaprenyl diphosphate synthase of Bacillus subtilis. The synthase reaction with the artificial substrate proceeded in the same stereochemical manner as that with the natural homoallylic substrate, isopentenyl diphosphate, but it had a full stop at the stage where a single condensation of the C6-homologue with an allylic primer is completed to form a chiral prenyl diphosphate with an extra methyl group at the 4-position. Allylic diphosphates that each have an extra methyl group at the 4-position were not accepted as substrates for this enzyme even when isopentenyl diphosphate was the homoallylic substrate. © 1989.

Type: Article
Title: Undecaprenyl diphosphate synthase reaction with artificial substrate homologues - novel behavior in the termination of prenyl chain elongation
DOI: 10.1016/S0040-4020(01)85127-9
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: http://discovery.ucl.ac.uk/id/eprint/1562964
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