UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions.

Kawakatsu, T; Huang, S-SC; Jupe, F; Sasaki, E; Schmitz, RJ; Urich, MA; Castanon, R; ... Ecker, JR; + view all (2016) Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions. Cell , 166 (2) pp. 492-505. 10.1016/j.cell.2016.06.044. Green open access

[img]
Preview
Text
Mott_Epigenomic diversity in a global collection of Arabidopsis thaliana accessions.pdf - ["content_typename_Accepted version" not defined]

Download (1MB) | Preview

Abstract

The epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how transposons and other structural variants shape the epigenome, with dramatic effects on immunity genes. The 1001 Epigenomes Project provides a comprehensive resource for understanding how variation in DNA methylation contributes to molecular and non-molecular phenotypes in natural populations of the most studied model plant.

Type: Article
Title: Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2016.06.044
Publisher version: https://doi.org/10.1016/j.cell.2016.06.044
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Arabidopsis, DNA Methylation, Epigenesis, Genetic, Epigenomics, Gene Expression Regulation, Plant, Genome, Plant, Transcriptome
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1562215
Downloads since deposit
134Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item