UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream

Auksztulewicz, R; Barascud, N; Cooray, G; Nobre, AC; Chait, M; Friston, K; (2017) The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream. Journal of Neuroscience , 37 (28) pp. 6751-6760. 10.1523/JNEUROSCI.0291-17.2017. Green open access

[img]
Preview
Text
Friston_6751.full.pdf - ["content_typename_Published version" not defined]

Download (1MB) | Preview

Abstract

Stimulus predictability can lead to substantial modulations of brain activity, such as shifts in sustained magnetic field amplitude, measured with magnetoencephalography (MEG). Here, we provide a mechanistic explanation of these effects using MEG data acquired from healthy human volunteers (N = 13, 7 female). In a source-level analysis of induced responses, we established the effects of orthogonal predictability manipulations of rapid tone-pip sequences (namely, sequence regularity and alphabet size) along the auditory processing stream. In auditory cortex, regular sequences with smaller alphabets induced greater gamma activity. Furthermore, sequence regularity shifted induced activity in frontal regions toward higher frequencies. To model these effects in terms of the underlying neurophysiology, we used dynamic causal modeling for cross-spectral density and estimated slow fluctuations in neural (postsynaptic) gain. Using the model-based parameters, we accurately explain the sensor-level sustained field amplitude, demonstrating that slow changes in synaptic efficacy, combined with sustained sensory input, can result in profound and sustained effects on neural responses to predictable sensory streams.

Type: Article
Title: The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.0291-17.2017
Publisher version: https://doi.org/10.1523/JNEUROSCI.0291-17.2017
Language: English
Additional information: © 2017 Auksztulewicz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in anymedium providedthatthe original work is properly attributed.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Auditory Processing, Dynamic Causal Modeling, Gain Modulation, Magnetoencephalography, Neural Oscillations, Predictive Coding, Free-Energy, Repetition Suppression, Mismatch Negativity, Sensory Signals, Visual-Cortex, Prediction, Responses, Brain, Adaptation, Attention
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1562100
Downloads since deposit
72Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item