Gonzalez, JA;
Iordanidou, P;
Strom, M;
Adamantidis, A;
Burdakov, D;
(2016)
Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks.
Nature Communications
, 7
, Article 113. 10.1038/ncomms11395.
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Abstract
The lateral hypothalamus (LH) controls energy balance. LH melanin-concentrating-hormone (MCH) and orexin/hypocretin (OH) neurons mediate energy accumulation and expenditure, respectively. MCH cells promote memory and appropriate stimulus-reward associations; their inactivation disrupts energy-optimal behaviour and causes weight loss. However, MCH cell dynamics during wakefulness are unknown, leaving it unclear if they differentially participate in brain activity during sensory processing. By fiberoptic recordings from molecularly defined populations of LH neurons in awake freely moving mice, we show that MCH neurons generate conditional population bursts. This MCH cell activity correlates with novelty exploration, is inhibited by stress and is inversely predicted by OH cell activity. Furthermore, we obtain brain-wide maps of monosynaptic inputs to MCH and OH cells, and demonstrate optogenetically that VGAT neurons in the amygdala and bed nucleus of stria terminalis inhibit MCH cells. These data reveal cell-type-specific LH dynamics during sensory integration, and identify direct neural controllers of MCH neurons.
| Type: | Article |
|---|---|
| Title: | Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ncomms11395 |
| Publisher version: | http://dx.doi.org/10.1038/ncomms11395 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | MELANIN-CONCENTRATING HORMONE, NEURONS IN-SITU, GLUTAMATERGIC TRANSMISSION, OREXIN/HYPOCRETIN NEURONS, LATERAL HYPOTHALAMUS, MICE LACKING, CIRCUIT, BEHAVIOR, SLEEP, STIMULATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1561355 |
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