UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults

Demnitz, N; Zsoldos, E; Mahmood, A; Mackay, CE; Kivimäki, M; Singh-Manoux, A; Dawes, H; ... Sexton, CE; + view all (2017) Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Frontiers in Aging Neuroscience , 9 , Article 155. 10.3389/fnagi.2017.00155. Green open access

[img]
Preview
Text
fnagi-09-00155.pdf - ["content_typename_Published version" not defined]

Download (2MB) | Preview

Abstract

Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.

Type: Article
Title: Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnagi.2017.00155
Publisher version: http://dx.doi.org/10.3389/fnagi.2017.00155
Language: English
Additional information: © 2017 Demnitz, Zsoldos, Mahmood, Mackay, Kivimäki, Singh-Manoux, Dawes, Johansen-Berg, Ebmeier and Sexton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: MRI, aging, balance, cognition, gait, gray matter, mobility
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/1560489
Downloads since deposit
64Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item