Lundgren, JD and Mocroft, A and Gatell, JM and Ledergerber, B and Monforte, AD and Hermans, P and Goebel, FD and Blaxhult, A and Kirk, O and Phillips, AN and EuroSIDA Study Grp, (2002) A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: Results from the EuroSIDA study. JOURNAL OF INFECTIOUS DISEASES , 185 (2) 178 - 187.
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The risk of clinical progression for human immunodeficiency virus (HIV)-infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up were examined. Results were validated in another 2 groups of patients (n = 1946 and n = 1442). In total, 200 patients (9.9%) experienced clinical progression during 5177 person-years (incidence, 3.9/100 years). The most recently measured CD4 cell count, virus load, and hemoglobin level all were independently related to the risk of clinical progression, as was a diagnosis of severe AIDS before the start of HAART. On the basis of these findings, a scoring system was derived (range, 0-17). A single unit increase in the score was associated with a 38% increased risk of clinical progression (relative hazard, 1.38; 95% confidence interval, 1.33-1.43; P < .0001). The scoring system was validated with remarkably good agreement in the 2 other cohorts. This system can be used in patient and resource management.
|Title:||A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: Results from the EuroSIDA study|
|Keywords:||HIV-INFECTED PATIENTS, HUMAN-IMMUNODEFICIENCY-VIRUS, CD4 CELL COUNT, PNEUMOCYSTIS-CARINII-PNEUMONIA, LONG-TERM SURVIVAL, RNA LEVELS, LYMPHOCYTE COUNTS, VIROLOGICAL FAILURE, PRIMARY PROPHYLAXIS, STAGING SYSTEM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Infection and Population Health|
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