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The role of non-parenchymal cells in liver growth

Malik, R; Selden, C; Hodgson, H; (2002) The role of non-parenchymal cells in liver growth. SEMIN CELL DEV BIOL , 13 (6) 425 - 431. 10.1016/S1084-9521(02)00130-1.

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Abstract

The main non-parenchymal cells of the liver, Kupffer cells, sinusoidal endothelial cells and stellate cells, participate in liver growth with respect to both their own proliferation, and effects on hepatocyte Proliferation. In the well-characterised paradigm of 70% partial hepatectomy, they undergo DNA synthesis and cell division 20-24 h later than the hepatocyte population. They exert both positive and negative influences on hepatocyte proliferation, including provision of an extracellular matrix-bound reservoir of hepatocyte growth factor that is activated after damage; priming of hepatocytes for DNA synthesis through rapid generation of TNF-alpha and IL-6; and generation of factors at later time points that curb hepatocyte DNA synthesis (IL-1, TGF-beta) and initiate reconstruction and reformation of matrix proteins.

Type: Article
Title: The role of non-parenchymal cells in liver growth
DOI: 10.1016/S1084-9521(02)00130-1
Keywords: liver regeneration, hepatocyte, non-parenchyrnal cells, REGENERATING RAT-LIVER, TUMOR-NECROSIS-FACTOR, FAT-STORING CELLS, HEPATIC STELLATE CELLS, PARTIAL-HEPATECTOMY, KUPFFER CELLS, FACTOR-BETA, HEPATOCYTE PROLIFERATION, FACTOR-ALPHA, ENDOTHELIAL-CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/156005
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