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Microstructural Diffusion-Weighted (VERDICT) MRI Metrics are Repeatable and Show Potential at Characterising Gleason 7 Prostate Cancer Non-Invasively

Johnston, E; Bonet-Carne, E; Pye, H; Clemente, J; Yvernault, B; Patel, D; Heavey, S; ... Punwani, S; + view all (2017) Microstructural Diffusion-Weighted (VERDICT) MRI Metrics are Repeatable and Show Potential at Characterising Gleason 7 Prostate Cancer Non-Invasively. Presented at: ISMRM 25th Annual Meeting & Exhibition, Honolulu, HI, USA.

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Abstract

In this study we we assess the repeatability of VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours) MRI parameters in prostate cancer consider their ability to distinguish between Gleason grades compared with the standard ADC model in 71 patients. Four of the parametric maps derived from the VERDICT technique were found to be satisfactorily repeatable for use as a clinical tool, and are capable of identifying a Gleason 7 component in prostate cancer where ADC failed to do so. VERDICT therefore holds great potential for use in clinical prostate cancer management pathways in the future.

Type: Conference item (Presentation)
Title: Microstructural Diffusion-Weighted (VERDICT) MRI Metrics are Repeatable and Show Potential at Characterising Gleason 7 Prostate Cancer Non-Invasively
Event: ISMRM 25th Annual Meeting & Exhibition
Location: Honolulu, HI, USA
Dates: 22 - 27 April 2017
Publisher version: http://www.ismrm.org/17/program_files/O32.htm
Language: English
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/1559316
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