UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Representation of Multiple Body Parts in the Missing-Hand Territory of Congenital One-Handers

Hahamy, A; Macdonald, SN; van den Heiligenberg, F; Kieliba, P; Emir, U; Malach, R; Johansen-Berg, H; ... Makin, TR; + view all (2017) Representation of Multiple Body Parts in the Missing-Hand Territory of Congenital One-Handers. Current Biology , 27 (9) pp. 1350-1355. 10.1016/j.cub.2017.03.053. Green open access

[img]
Preview
Text
Makin_1-s2.0-S0960982217303524-main.pdf - ["content_typename_Published version" not defined]

Download (1MB) | Preview
[img]
Preview
Image
Makin_representation_multiple Figure1final_1.tif - ["content_typename_Published version" not defined]

Download (4MB) | Preview
[img]
Preview
Image
Makin_representation_multiple Figure2final_2.tif - ["content_typename_Published version" not defined]

Download (4MB) | Preview
[img]
Preview
Image
Makin_representation_multiple Figure3final_3.tif - ["content_typename_Published version" not defined]

Download (1MB) | Preview
[img]
Preview
Image
Makin_representation_multiple Figure4final_4.tif - ["content_typename_Published version" not defined]

Download (1MB) | Preview

Abstract

Individuals born without one hand (congenital one-handers) provide a unique model for understanding the relationship between focal reorganization in the sensorimotor cortex and everyday behavior. We previously reported that the missing hand’s territory of one-handers becomes utilized by its cortical neighbor (residual arm representation), depending on residual arm usage in daily life to substitute for the missing hand’s function [1 ; 2]. However, the repertoire of compensatory behaviors may involve utilization of other body parts that do not cortically neighbor the hand territory. Accordingly, the pattern of brain reorganization may be more extensive [3]. Here we studied unconstrained compensatory strategies under ecological conditions in one-handers, as well as changes in activation, connectivity, and neurochemical profile in their missing hand’s cortical territory. We found that compensatory behaviors in one-handers involved multiple body parts (residual arm, lips, and feet). This diversified compensatory profile was associated with large-scale cortical reorganization, regardless of cortical proximity to the hand territory. Representations of those body parts used to substitute hand function all mapped onto the cortical territory of the missing hand, as evidenced by task-based and resting-state fMRI. The missing-hand territory also exhibited reduced GABA levels, suggesting a reduction in connectional selectivity to enable the expression of diverse cortical inputs. Because the same body parts used for compensatory purposes are those showing increased representation in the missing hand’s territory, we suggest that the typical hand territory may not necessarily represent the hand per se, but rather any other body part that shares the functionality of the missing hand [4].

Type: Article
Title: Representation of Multiple Body Parts in the Missing-Hand Territory of Congenital One-Handers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2017.03.053
Publisher version: http://doi.org/10.1016/j.cub.2017.03.053
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, PHANTOM-LIMB PAIN, CORTICAL REORGANIZATION, ARM AMPUTATION, CORTEX, AMPUTEES, BRAIN, PATTERNS, MAP, ORGANIZATION, PLASTICITY, amelia; neuroimaging; phantom pain; plasticity; sensorimotor; one-handers
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1559162
Downloads since deposit
81Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item