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On the existence of a central respiratory oxygen sensor

Gourine, AV; Funk, GD; (2017) On the existence of a central respiratory oxygen sensor. Journal of Applied Physiology , 123 (5) pp. 1344-1349. 10.1152/japplphysiol.00194.2017. Green open access

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Abstract

A commonly held view that dominates both the scientific and educational literature is that in terrestrial mammals the central nervous system lacks a physiological hypoxia sensor capable of triggering increases in lung ventilation in response to decreases in PO2 of the brain parenchyma. Indeed, a normocapnic hypoxic ventilatory response has never been observed in humans following bilateral resection of the carotid bodies. In contrast, almost complete or partial recovery of the hypoxic ventilatory response after denervation/removal of the peripheral respiratory oxygen chemoreceptors has been demonstrated in many experimental animals when assessed in an awake state. In this essay we review the experimental evidence obtained using in vitro and in vivo animal models, results of human studies, and discuss potential mechanisms underlying the effects of CNS hypoxia on breathing. We consider experimental limitations and discuss potential reasons why the recovery of the hypoxic ventilatory response has not been observed in humans. We review recent experimental evidence suggesting that the lower brainstem contains functional respiratory oxygen sensitive elements capable of stimulating respiratory activity independently of peripheral chemoreceptor input.

Type: Article
Title: On the existence of a central respiratory oxygen sensor
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/japplphysiol.00194.2017
Publisher version: http://dx.doi.org/10.1152/japplphysiol.00194.2017
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Astrocyte, brainstem, carotid body, chemosensitivity, hypoxic ventilatory response
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1558497
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