UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Measuring compensation in neurodegeneration using MRI

Gregory, S; Long, JD; Tabrizi, SJ; Rees, G; (2017) Measuring compensation in neurodegeneration using MRI. Current Opinion in Neurology , 30 (4) pp. 380-387. 10.1097/WCO.0000000000000469. Green open access

[thumbnail of Gregory_Measuring_compensation_neurodegeneration_MRI.pdf]
Preview
Text
Gregory_Measuring_compensation_neurodegeneration_MRI.pdf - Accepted Version

Download (388kB) | Preview

Abstract

PURPOSE OF REVIEW: Despite signs of cortical and subcortical loss, patients with prodromal and early-stage neurodegenerative disease are able to perform at a level comparable to the normal population. It is presumed that the onset of compensatory processes, that is changes in brain activation within a function-specific network or in the recruitment of a region outside of the task-network, underlies this maintenance of normal performance. However, in most studies to date, increased brain activity is not correlated with indices of both disease and performance and what appears to be compensation could simply be a symptom of neurodegeneration. RECENT FINDINGS: MRI studies have explored compensation in neurodegenerative disease, claiming that compensation is evident across a number of disorders, including Alzheimer's and Parkinson's disease, but generally always in early stages; after this point, compensation is generally no longer able to operate under the severe burden of disease. However, none of these studies explicitly adopted a particular model of compensation. Thus, we also discuss our recent attempts to operationalize compensation for empirical testing. SUMMARY: There is clear evidence of compensatory processes in the early stages of neurodegenerative disease. However, for a more complete understanding, this requires more explicit empirical modelling.

Type: Article
Title: Measuring compensation in neurodegeneration using MRI
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/WCO.0000000000000469
Publisher version: http://dx.doi.org/10.1097/WCO.0000000000000469
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Compensation, Neurodegeneration, Magnetic Resonance Imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1558230
Downloads since deposit
91Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item