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Tyrosine hydroxylase and levodopa responsive dystonia.

Fletcher, NA; Holt, IJ; Harding, AE; Nygaard, TG; Mallet, J; Marsden, CD; (1989) Tyrosine hydroxylase and levodopa responsive dystonia. J Neurol Neurosurg Psychiatry , 52 (1) pp. 112-114.

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Abstract

It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.

Type: Article
Title: Tyrosine hydroxylase and levodopa responsive dystonia.
Location: England
Keywords: Chromosome Mapping, Chromosomes, Human, Pair 11, DNA Probes, Dystonia, Genetic Linkage, Humans, Levodopa, Parkinson Disease, Pedigree, Polymorphism, Restriction Fragment Length, Tyrosine 3-Monooxygenase
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/1558192
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