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Myocyte loss in chronic heart failure.
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This study examined whether or not there is progressive loss of individual myocytes in established heart failure, accounting for the progressive left ventricular dysfunction; whether such loss is hy necrosis or apoptosis; and whether such loss is more pronounced in ischaemic heart disease or idiopathic dilated cardiomyopathy, Tissue for patients undergoing cardiac transplantation for clinical end-stage heart disease was used, The clinical diagnosis was not known to the observer at the time of analysis. Indices of potential myocyte loss mere: detection of apoptotic nuclei in situ, using the TUNEL method, immunohistochemistry for CD120a, CD120b, CD95, perforin and granzyme B; binding of C9 complex; and lipofuscin deposition within macrophages, Interstitial macrophages and T cells and their relationship to myocyte loss were also examined. There is indeed low grade myocyte loss in chronic heart failure, but there was no difference between the disease groups; rather, there was marked patient-to-patient variation within each category, Thus in chronic heart failure myocyte loss does occur, and both necrosis and apoptosis contribute to this loss, irrespective of the underlying nature of the disease, Any mechanism which accounts for myocyte loss must be common to both conditions, rather than specific for a pre-operative diagnosis, Copyright (C) 1999 John Wiley & Sons, Ltd.
|Title:||Myocyte loss in chronic heart failure|
|Keywords:||apoptosis, myocyte, chronic heart failure, cadiomyopathy, ischaemic heart disease, necrosis, NECROSIS-FACTOR-ALPHA, DILATED CARDIOMYOPATHY, CELL-DEATH, MYOCARDIAL-INFARCTION, DNA FRAGMENTATION, INDUCED APOPTOSIS, MESSENGER-RNA, PROTEIN, EXPRESSION, DOGS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Epidemiology and Public Health
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