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Novel Insights into Membrane Targeting of B Cell Lymphoma

de Winde, CM; Elfrink, S; van Spriel, AB; (2017) Novel Insights into Membrane Targeting of B Cell Lymphoma. Trends in Cancer , 3 (6) pp. 442-453. 10.1016/j.trecan.2017.04.006. Green open access

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Abstract

Standard therapy of patients with B cell non-Hodgkin lymphoma (B-NHL) predominantly consists of chemotherapy combined with anti-CD20 (e.g., rituximab) immunotherapy. However, relapse of aggressive B-NHL occurs frequently, and this may coincide with therapy resistance. This demonstrates the urgent need for exploring new lymphoma-targeted therapies. We review here recent insights in the pathophysiology of B-NHL and discuss CD20 and three alternative membrane targets (B cell receptor, immune checkpoints PD-1/PD-L1, tetraspanin CD37) that are currently in the spotlight for B-NHL treatment. Furthermore, we present a novel concept in which the plasma membrane organization of the lymphoma B cell determines the efficacy of membrane-targeted therapies, and this has consequences for treatment application and clinical outcome in patients with B cell lymphoma.

Type: Article
Title: Novel Insights into Membrane Targeting of B Cell Lymphoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trecan.2017.04.006
Publisher version: http://doi.org/10.1016/j.trecan.2017.04.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Non-Hodgkin lymphoma; B cell; immunotherapy; membrane target; membrane organization
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1558078
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