UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy.

Sharma, RA; Decatris, MP; Santhanam, S; Roy, R; Osman, AE; Clarke, CB; Khanna, S; (2003) Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy. Cancer Chemother Pharmacol , 52 (5) pp. 367-370. 10.1007/s00280-003-0679-8.

Full text not available from this repository.

Abstract

PURPOSE: The development of liver metastases from breast cancer is associated with a very poor prognosis, estimated at 4 months median survival. Since treatment with many chemotherapeutic agents is relatively contraindicated, we assessed the safety, tolerability and potential efficacy of combination chemotherapy with vinorelbine and cisplatin (ViP). METHOD: Pilot study in 11 patients with histologically confirmed breast carcinoma, radiological evidence of liver metastases and serum bilirubin greater than 1.5 times the upper limit of normal. Patients received up to six cycles of cisplatin (75 mg/m2) every 21 days and vinorelbine (20 mg/m2) on days 1 and 8 of every 21-day cycle. Measurement of liver lesions was performed on CT scan every 8 weeks into treatment. RESULTS: The most frequently reported adverse event was myelosuppression. Other adverse effects included nausea, vomiting and mild neurotoxicity. Two patients died after one treatment with ViP, one of whom suffered an intracerebral haemorrhage that was possibly treatment-related. Improvement in liver function tests was observed in 10 patients, and mean time to normalization of bilirubin levels was 36 days. Partial responses were documented radiologically in 7 out of 11 patients treated. Median overall survival from trial entry was 6.5 months (range 11-364 days), with one patient alive 13 months from trial entry. CONCLUSION: Normalization of liver function is possible with ViP treatment of metastatic breast cancer, offering the potential to prolong survival. Phase II clinical trials of this regimen in this patient group should include measurement of quality of life in order to assess risk versus benefit.

Type: Article
Title: Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy.
Location: Germany
DOI: 10.1007/s00280-003-0679-8
Keywords: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Diseases, Breast Neoplasms, Cisplatin, Female, Humans, Liver Failure, Liver Function Tests, Liver Neoplasms, Middle Aged, Pilot Projects, Survival Analysis, Tomography, X-Ray Computed, Vinblastine, Vinorelbine
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1556884
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item