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Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish

Chen, S; Reichert, S; Singh, C; Oikonomou, G; Rihel, J; Prober, DA; (2017) Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron , 95 (1) 153-168.e6. 10.1016/j.neuron.2017.06.001. Green open access

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Abstract

Light affects sleep and wake behaviors by providing an indirect cue that entrains circadian rhythms and also by inducing a direct and rapid regulation of behavior. While circadian entrainment by light is well characterized at the molecular level, mechanisms that underlie the direct effect of light on behavior are largely unknown. In zebrafish, a diurnal vertebrate, we found that both overexpression and mutation of the neuropeptide prokineticin 2 (Prok2) affect sleep and wake behaviors in a light-dependent but circadian-independent manner. In light, Prok2 overexpression increases sleep and induces expression of galanin (galn), a hypothalamic sleep-inducing peptide. We also found that light-dependent, Prok2-induced sedation requires prokineticin receptor 2 (prokr2) and is strongly suppressed in galn mutants. These results suggest that Prok2 antagonizes the direct wake-promoting effect of light in zebrafish, in part through the induction of galn expression in the hypothalamus.

Type: Article
Title: Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2017.06.001
Publisher version: http://doi.org/10.1016/j.neuron.2017.06.001
Language: English
Additional information: © 2017 Elsevier Inc. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, SUPRACHIASMATIC NUCLEI, LARVAL ZEBRAFISH, CIRCADIAN REGULATION, OLFACTORY-BULB, MICE LACKING, SYSTEM, IDENTIFICATION, CLOCK, WAKEFULNESS, MELANOPSIN, prokineticin 2; galanin; sleep; circadian rhythm; masking; zebrafish
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1556374
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