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Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy

Kimber, TE; Orrel, RW; King, RHM; Ginsberg, L; (2003) Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy. J PERIPHER NERV SYST , 8 (1) 13 - 16.

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) may cause significant disability, but severe respiratory complications are uncommon. We describe the case of a 49-year-old man with clinical features of CIDP for 5 years who died of respiratory failure. Post-mortem findings of denervation in diaphragm muscle and axonal loss in phrenic nerve are presented. Severe ventilatory failure may occur in CIDP when neuropathy affects the respiratory muscles. Attention to early clinical features of respiratory insufficiency may facilitate the prevention of more severe features of respiratory failure.

Type: Article
Title: Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy
Keywords: chronic inflammatory demyelinating, polyneuropathy, phrenic nerve, pathology, ventilatory failure, MULTIFOCAL MOTOR NEUROPATHY, POLYRADICULONEUROPATHY, CRITERIA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/155609
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