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Liver cells: biology to therapeutics

Hodgson, H; (2003) Liver cells: biology to therapeutics. Clinical Medicine , 3 (2) pp. 161-165.

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Abstract

The liver has a remarkable capacity to regenerate after injury. Recent work has demonstrated that repair may call upon either the division of pre-existing mature cells, or the expansion of intrahepatic progenitor cells. Furthermore, progenitors may migrate into the liver from the bone marrow. Understanding and exploiting the cell biology of the liver provides the basis for innovational treatment, including the use of growth factors, transplantation of isolated cells, genetic manipulation of hepatocytes and liver cell progenitors, and the development of artificial liver support systems

Type: Article
Title: Liver cells: biology to therapeutics
Additional information: DA - 20030509 IS - 1470-2118 LA - eng PT - Journal Article RN - 67256-21-7 (Hepatocyte Growth Factor) SB - IM
Keywords: biology, bone, Bone Marrow, BONE-MARROW, CAPACITY, cell, Cell Biology, Cell Transplantation, CELLS, development, EXPANSION, Extracorporeal Circulation, factors, Gene Transfer Techniques, genetic, growth, GROWTH FACTOR, growth factors, GROWTH-FACTOR, GROWTH-FACTORS, hepatocyte, Hepatocyte Growth Factor, HEPATOCYTES, IM, injuries, injury, LA, liver, Liver Diseases, Liver Regeneration, MARROW, May, Metabolism, Inborn Errors, physiology, PROGENITOR CELLS, repair, support, surgery, SYSTEM, SYSTEMS, therapeutic, therapeutics, transplantation, treatment, understanding, Use, work
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/155557
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