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Brain Computations in Schizophrenia

Adams, RA; Friston, KJ; (2016) Brain Computations in Schizophrenia. In: The Neurobiology of Schizophrenia. (pp. 283-295).

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Abstract

© 2016 Elsevier Inc. All rights reserved. Because the brain performs Bayesian inference for the causes of its sensory data, the synaptic gain could encode the precision (inverse variance) of its beliefs using a hierarchical generative model and predictive coding. Several neurobiological risk factors for schizophrenia (NMDAR and GABAergic interneuron hypofunction) reduce both synaptic and "oscillatory" gain at high hierarchical areas. This could impair the encoding of precision at higher levels of the brain's hierarchical model and increase expected precision at lower levels. This imbalance can account for many neurobiological and phenomenological findings in schizophrenia. Striatal D2R hyperactivity may increase the precision of current policies by inhibiting behavioral or cognitive switching. This could be a (dysfunctional) consequence of or even an attempt to compensate for prefrontal or hippocampal pathology. This D2R hyperactivity may also reduce learning from positive outcomes and affect the encoding of motivational (or informational) salience.

Type: Book chapter
Title: Brain Computations in Schizophrenia
ISBN-13: 9780128018293
DOI: 10.1016/B978-0-12-801829-3.00024-0
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/1553633
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