Lucas, M and Gadola, S and Meier, U and Young, NT and Harcourt, G and Karadimitris, A and Coumi, N and Brown, D and Dusheiko, G and Cerundolo, V and Klenerman, P (2003) Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection. J VIROL , 77 (3) 2251 - 2257. 10.1128/JVI.77.3.2251-2257.2003.
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Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
|Title:||Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection|
|Keywords:||NKT CELLS, INTRAHEPATIC LYMPHOCYTES, CD1D TETRAMERS, IN-VIVO, ACTIVATION, LIVER, EXPANSION, IL-15|
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