Lucas, M; Gadola, S; Meier, U; Young, NT; Harcourt, G; Karadimitris, A; ... Klenerman, P; + view all Lucas, M; Gadola, S; Meier, U; Young, NT; Harcourt, G; Karadimitris, A; Coumi, N; Brown, D; Dusheiko, G; Cerundolo, V; Klenerman, P; - view fewer (2003) Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection. J VIROL , 77 (3) 2251 - 2257. 10.1128/JVI.77.3.2251-2257.2003.
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Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
|Title:||Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection|
|Keywords:||NKT CELLS, INTRAHEPATIC LYMPHOCYTES, CD1D TETRAMERS, IN-VIVO, ACTIVATION, LIVER, EXPANSION, IL-15|
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