Zeman, AZJ and Kidd, D and McLean, BN and Kelly, MA and Francis, DA and Miller, DH and Kendall, BE and Rudge, P and Thompson, EJ and McDonald, WI (1996) A study of oligoclonal band negative multiple sclerosis. J NEUROL NEUROSUR PS , 60 (1) 27 - 30.
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Objectives-to determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis.Methods-retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multiple sclerosis with and without intrathecal synthesis of oligoclonal IgG.Results-thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis. The results of oligoclonal banding proved to have been equivocal in 14 of 34; the clinical diagnosis of multiple sclerosis was questionable in 8 of 34. The remaining 12 patients with ''true'' OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls. Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence of intrathecal synthesis of OCBs.Conclusions-OCB negative clinically definite multiple sclerosis is rare and should be diagnosed with caution; in unequivocal cases it seems to have a relatively benign prognosis.
|Title:||A study of oligoclonal band negative multiple sclerosis|
|Keywords:||multiple sclerosis, oligoclonal bands, IMMUNOGLOBULIN-G, GUIDELINES, DIAGNOSIS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > IoN - Neuroinflammation|
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