Rich, PR;
(2017)
Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies.
Biochemical Society Transactions
, 45
(3)
pp. 813-829.
10.1042/BST20160139.
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Abstract
Mitochondrial cytochrome c oxidase is a member of a diverse superfamily of haem–copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures. This reaction cycle is coupled to the translocation of protons across the inner mitochondrial membrane in which it is located. The likely mechanism by which this occurs, derived in significant part from studies of bacterial homologues, is presented. These mechanisms of catalysis and coupling, together with current alternative proposals of underlying mechanisms, are critically reviewed.
| Type: | Article |
|---|---|
| Title: | Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1042/BST20160139 |
| Publisher version: | http://doi.org/10.1042/BST20160139 |
| Language: | English |
| Additional information: | © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, COPPER RESPIRATORY OXIDASES, PROTON-TRANSFER PATHWAYS, ACTIVE-SITE TYROSINE, PARACOCCUS-DENITRIFICANS, RHODOBACTER-SPHAEROIDES, ELECTRON-TRANSFER, OXYGEN REDUCTION, FTIR SPECTROSCOPY, HYDROGEN-PEROXIDE, TERMINAL OXIDASES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1553109 |
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