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Structure of human factor VIII.

Vehar, GA; Keyt, B; Eaton, D; Rodriguez, H; O'Brien, DP; Rotblat, F; Oppermann, H; ... Capon, DJ; + view all (1984) Structure of human factor VIII. Nature , 312 (5992) pp. 337-342.

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Abstract

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.

Type: Article
Title: Structure of human factor VIII.
Location: England
Keywords: Amino Acid Sequence, Ceruloplasmin, Factor VIII, Humans, Peptide Fragments, Protein Conformation, Protein Precursors, Thrombin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1553024
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