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Ketamine treatment for depression: opportunities for clinical innovation and ethical foresight

Singh, I; Morgan, C; Curran, V; Nutt, D; Schlag, A; McShane, R; (2017) Ketamine treatment for depression: opportunities for clinical innovation and ethical foresight. The Lancet Psychiatry , 4 (5) pp. 419-426. 10.1016/S2215-0366(17)30102-5. Green open access

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Abstract

We present a review and analysis of the ethical considerations in off-label ketamine use for severe, treatment-resistant depression. The analysis of ethical considerations is contextualised in an overview of the evidence for ketamine use in depression, and a review of the drug's safety profile. We find that, based on current evidence, ketamine use for severe, treatment-resistant depression does not violate ethical principles; however, clinicians and professional bodies must take steps to ensure that guidelines for good practice are enacted, that all experimental and trial data are made available through national registries, and that the risk potential of ketamine treatment continues to be monitored and modelled. We conclude with a set of key recommendations for oversight bodies that would support safe, effective, and ethical use of ketamine in depression.

Type: Article
Title: Ketamine treatment for depression: opportunities for clinical innovation and ethical foresight
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2215-0366(17)30102-5
Publisher version: https://doi.org/10.1016/S2215-0366(17)30102-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/1552865
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