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Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A

McShane, H; Behboudi, S; Goonetilleke, N; Brookes, R; Hill, AVS; (2002) Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. INFECT IMMUN , 70 (3) 1623 - 1626. 10.1128/IAI.70.3.1623-1626.2002.

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Abstract

Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4(+)- or CD8(+)-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8(+) T cells can play a protective role against tuberculosis.

Type:Article
Title:Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A
DOI:10.1128/IAI.70.3.1623-1626.2002
Keywords:VACCINIA VIRUS ANKARA, BOOST VACCINATION REGIMEN, CYTOTOXIC T-LYMPHOCYTES, ENHANCED IMMUNOGENICITY, INFECTION, CD4(+), ACTIVATION, INDUCTION, EFFICACY, HELP
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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