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Complement dependence of localisation of aggregated IgG in germinal centres.

Papamichail, M; Gutierrez, C; Embling, P; Johnson, P; Holborow, EJ; Pepys, MB; (1975) Complement dependence of localisation of aggregated IgG in germinal centres. Scand J Immunol , 4 (4) pp. 343-347.

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Abstract

In vivo decomplementation of mice with cobra factor completely prevented trapping of aggregated human IgG within splenic germinal centres. Observations of the intrasplenic position of the aggregated material within 8 hr of its injection into normal and decomplemented mice suggest that the early phase of localisation in germinal centres depends on binding to lymphocyte C3 receptors.

Type: Article
Title: Complement dependence of localisation of aggregated IgG in germinal centres.
Location: England
Keywords: Animals, Binding Sites, Complement C3, Complement System Proteins, Female, Germ Cells, Hot Temperature, Immunoglobulin G, Injections, Intraperitoneal, Male, Mice, Mice, Inbred BALB C, Snake Venoms, Spleen
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/1552181
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