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The membrane phenotype of T-prolymphocytic leukaemia.

Catovsky, D; Wechsler, A; Matutes, E; Gomez, R; Bourikas, G; Cherchi, M; Pepys, EO; ... Greaves, MF; + view all (1982) The membrane phenotype of T-prolymphocytic leukaemia. Scand J Haematol , 29 (5) pp. 398-404.

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Abstract

Cells from 13 cases of T-prolymphocytic leukaemia (T-PLL) were studied with a battery of immunological techniques in order to define their membrane phenotype. All cases were E-rosette positive and were negative with OKT6, anti-HLA-DR, anti-Ig and M-rosettes; in 3, 20-30% of the cells had receptors for C3b. 7 cases had predominantly a 'helper/inducer' T-subset phenotype, (OKT4+, OKT8-) and 4 had a 'suppressor/cytotoxic' phenotype (OKT8+, OKT4-). Cells in 2 cases coexpressed OKT4 and OKT8 in 48% and 95% of prolymphocytes and in another, both OKT4 and OKT8 were negative. Terminal transferase (TdT) was negative by IF in all the cases, but a low positive level was detected biochemically in one. Although T-PLL appears to be heterogenous in respect of membrane phenotype, the observation of unexpected features in 8 of the cases raises the possibility that it may originate in a cell of intermediate maturation between late thymocytes and mature T-lymphocytes. These features plus the clinical manifestation of the disease - typical morphology, splenomegaly, lymphadenopathy, skin lesions, high WBC and aggressive clinical course - help define T-PLL as a distinct clinicopathological entity.

Type: Article
Title: The membrane phenotype of T-prolymphocytic leukaemia.
Location: Denmark
Keywords: Aged, Antibodies, Monoclonal, Female, Histocompatibility Antigens Class II, Humans, Leukemia, Lymphoid, Male, Middle Aged, Phenotype, Receptors, Antigen, B-Cell, Receptors, Antigen, T-Cell, Rosette Formation, T-Lymphocytes, Helper-Inducer, T-Lymphocytes, Regulatory
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/1552120
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