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Amyloid P-component in human glomerular basement membrane. Abnormal patterns of immunofluorescent staining in glomerular disease.

Dyck, RF; Evans, DJ; Lockwood, CM; Rees, AJ; Turner, D; Pepys, MB; (1980) Amyloid P-component in human glomerular basement membrane. Abnormal patterns of immunofluorescent staining in glomerular disease. Lancet , 2 (8195 pt ) pp. 606-609.

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Abstract

Serum amyloid P-component (SAP) is a normal plasma protein and is a constituent of normal human glomerular basement membrane. Immunofluorescence with anti-SAP antibody produced characteristic linear staining along the glomerular basement membrane in normal kidney. Distinctive abnormal staining patterns were seen in renal biopsy specimens from patients with diabetes, membranous glomerulonephritis, mesangiocapillary nephritis, systemic vasculitis, Goodpasture's syndrome.

Type: Article
Title: Amyloid P-component in human glomerular basement membrane. Abnormal patterns of immunofluorescent staining in glomerular disease.
Location: England
Keywords: Amyloid, Anti-Glomerular Basement Membrane Disease, Autoantibodies, Basement Membrane, Cross Reactions, Diabetic Nephropathies, Fluorescent Antibody Technique, Glomerulonephritis, Humans, Kidney Glomerulus, Serum Amyloid P-Component, Staining and Labeling
URI: http://discovery.ucl.ac.uk/id/eprint/1552090
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