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Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient.

Dische, FE; Wernstedt, C; Westermark, GT; Westermark, P; Pepys, MB; Rennie, JA; Gilbey, SG; (1988) Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient. Diabetologia , 31 (3) pp. 158-161.

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Abstract

A patient with Type 1 (insulin-dependent) diabetes mellitus developed localised amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils.

Type: Article
Title: Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient.
Location: Germany
Keywords: Adult, Amino Acid Sequence, Amino Acids, Amyloid, Diabetes Mellitus, Type 1, Humans, Insulin, Male, Skin
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/1552023
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