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Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force

Fischer, P; Pogosyan, A; Cheeran, B; Green, AL; Aziz, TZ; Hyam, J; Little, S; ... Tan, H; + view all (2017) Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force. Experimental Neurology , 293 pp. 53-61. 10.1016/j.expneurol.2017.03.015. Green open access

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Abstract

Motor imagery involves cortical networks similar to those activated by real movements, but the extent to which the basal ganglia are recruited is not yet clear. Gamma and beta oscillations in the subthalamic nucleus (STN) vary with the effort of sustained muscle activity. We recorded local field potentials in Parkinson's disease patients and investigated if similar changes can be observed during imagined gripping at three different 'forces'. We found that beta activity decreased significantly only for imagined grips at the two stronger force levels. Additionally, gamma power significantly scaled with increasing imagined force. Thus, in combination, these two spectral features can provide information about the intended force of an imaginary grip even in the absence of sensory feedback. Modulations in the two frequency bands during imaginary movement may explain the rehabilitating benefit of motor imagery to improve motor performance. The results also suggest that STN LFPs may provide useful information for brain-machine interfaces.

Type: Article
Title: Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.expneurol.2017.03.015
Publisher version: http://doi.org/10.1016/j.expneurol.2017.03.015
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Basal ganglia, Beta suppression, Brain computer interface, Brain machine interface, Force decoding, Gamma oscillations, Imagined force, Motor imagery, Neuro-feedback, STN
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1551126
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