Noyce, A;
Bandopadhyay, R;
(2017)
Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.
In: Beart, P and Robinson, M and Rattray, M and Maragakis, NJ, (eds.)
Neurodegenerative Diseases: Pathology, Mechanisms, and Potential Therapeutic Targets.
(pp. 55-92).
Springer: Cham, Switzerland.
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Abstract
PD is a common and a debilitating degenerative movement disorder. The number of patients is increasing worldwide and as yet there is no cure for the disease. The majority of existing treatments target motor symptom control. Over the last two decades the impact of the genetic contribution to PD has been appreciated. Significant discoveries have been made, which have advanced our understanding of the pathophysiological and molecular basis of PD. In this chapter we outline current knowledge of the clinical aspects of PD and the basic mechanistic understanding.
| Type: | Book chapter |
|---|---|
| Title: | Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview |
| ISBN-13: | 978-3-319-57193-5 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-57193-5_3 |
| Publisher version: | https://doi.org/10.1007/978-3-319-57193-5_3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Autophagy/lysosomal dysfunction, Clinical features, Environmental factors, Genetic risk, Lewy body, Neuroinflammation, Parkinson’s disease, Pathology, Prion-like mechanisms, Treatment, Autonomic Nervous System Diseases, Brain, Dementia, Glucosylceramidase, Humans, Hypokinesia, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Lewy Bodies, Mitochondria, Muscle Rigidity, Olfaction Disorders, Oxidative Stress, Parkinson Disease, Postural Balance, Protein Aggregation, Pathological, Protein Deglycase DJ-1, Sleep Wake Disorders, Tremor, Ubiquitin-Protein Ligases, alpha-Synuclein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1549674 |
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