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Novel silicon-doped hydroxyapatite (Si-HA) for biomedical coatings: An in vitro study using acellular simulated body fluid

Thian, ES; Huang, J; Best, SM; Barber, ZH; Bonfield, W; (2006) Novel silicon-doped hydroxyapatite (Si-HA) for biomedical coatings: An in vitro study using acellular simulated body fluid. J BIOMED MATER RES B , 76B (2) 326 - 333. 10.1002/jbm.b.30368.

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Abstract

Magnetron co-sputtering was used to produce silicon-doped hydroxyapatite (Si-HA) as coatings intended for potential applications such as orthopedic and dental implants. It was found that the crystallinity of the as-sputtered coatings increased after annealing, resulting in a nanocrystalline apatite structure. Subsequently, the bioactivity of the coatings was evaluated in an acellular simulated body fluid (SBF). Physicochemical evaluation demonstrated that a carbonate-containing apatite layer, which is essential for bonding at the bone/implant interface, was formed on the coating surfaces after immersion in SBF between 4 and 7 days. The annealed coatings exhibited enhanced bioactivity and chemical stability under physiological conditions, as compared with the as-sputtered coatings. It is proposed that the rate at which the carbonate-containing apatite layer forms is dependent on the scale factor of the structure. A nanocrystalline structure can provide a higher number of nucleation sites for the formation of apatite crystallites, leading to a more rapid precipitation of carbonate-containing apatite layer. This work shows that Si-HA coatings offer considerable potential for applications in hard tissue replacement, owing to their ability to form a carbonate-containing apatite layer rapidly. (c) 2005 Wiley Periodicals, Inc.

Type:Article
Title:Novel silicon-doped hydroxyapatite (Si-HA) for biomedical coatings: An in vitro study using acellular simulated body fluid
DOI:10.1002/jbm.b.30368
Keywords:hydroxyapatite, silicon, coating, sputtering, in vitro, CALCIUM-PHOSPHATE COATINGS, SURFACE CHARACTERISTICS, BIOACTIVE GLASS, THIN-FILMS, APATITE, VIVO, REQUIREMENT, IMPLANTS, BEHAVIOR, BIOCERAMICS
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering

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