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Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT)

Hutchinson, JC; Shelmerdine, SC; Simcock, IC; Sebire, NJ; Arthurs, OJ; (2017) Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT). British Journal of Radiology , Article 20170113. 10.1259/bjr.20170113. (In press). Green open access

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Abstract

Microfocus CT (micro-CT) has traditionally been used in industry and preclinical studies, although it may find new applicability in the routine clinical setting. It can provide high-resolution three-dimensional digital imaging data sets to the same level of detail as microscopic examination without the need for tissue dissection. Micro-CT is already enabling non-invasive detailed internal assessment of various tissue specimens, particularly in breast imaging and early gestational fetal autopsy, not previously possible from more conventional modalities such as MRI or CT. In this review, we discuss the technical aspects behind micro-CT image acquisition, how early work with small animal studies have informed our knowledge of human disease and the imaging performed so far on human tissue specimens. We conclude with potential future clinical applications of this novel and emerging technique.

Type: Article
Title: Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1259/bjr.20170113
Publisher version: http://dx.doi.org/10.1259/bjr.20170113
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1549500
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