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Structure and chromosomal localization of the human 2‘,3’‐cyclic nucleotide 3‘‐phosphodiesterase gene

DOUGLAS, AJ; FOX, MF; ABBOTT, CM; HINKS, LJ; SHARPE, G; POVEY, S; THOMPSON, RJ; (1992) Structure and chromosomal localization of the human 2‘,3’‐cyclic nucleotide 3‘‐phosphodiesterase gene. Annals of Human Genetics , 56 (3) pp. 243-254. 10.1111/j.1469-1809.1992.tb01149.x.

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Abstract

Human brain cDNA clones for the myelin associated enzyme 2′ 3′ ‐cyclic nucleotide 3′ ‐phosphodiesterase (CNPase) have been isolated and sequenced. The only 5′ untranslated region (UTR) sequence found was that of a human CNPII mRNA, with no direct evidence for a CNPI mRNA. Human CNPase cDNAs were used to isolate genomic clones containing the human CNPase gene which is 9 kb long. Four exons were identified, separated by three introns, and the sequence of each exon and intron/exon boundary has been established. The polymerase chain reaction (PCR) was used to detect the presence of the human CNPase gene in DNA from a panel of rodent/human somatic cell hybrids. By this means the human CNPase gene was mapped to chromosome 17. In situ hybridization of a human CNPase genomic clone to metaphase chromosomes further localized this gene to chromosomal band 17q21. Copyright © 1992, Wiley Blackwell. All rights reserved

Type: Article
Title: Structure and chromosomal localization of the human 2‘,3’‐cyclic nucleotide 3‘‐phosphodiesterase gene
DOI: 10.1111/j.1469-1809.1992.tb01149.x
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1549125
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