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The importance of mesenchymal factors in the differentiation of chick epidermis I. the differentiation in culture of the isolated epidermis of the embryonic chick and its response to excess vitamin A

McLoughlin, CB; (1961) The importance of mesenchymal factors in the differentiation of chick epidermis I. the differentiation in culture of the isolated epidermis of the embryonic chick and its response to excess vitamin A. Journal of Embryology and Experimental Morphology , 9 (3) pp. 370-384.

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Abstract

It is well established that in the developing chick the underlying mesenchyme initiates the appearance of specific epidermal derivatives, e.g. feathers (Sengel, 1956), claws (Cairns & Saunders, 1954), and the preen gland (Gomot, 1958). On the other hand, it is not yet known to what extent the epidermis is independent of mesenchymal intervention for its basic differentiation into a stratified, squamous epithelium. Sobel's (1958) work on the 8-day chick pituitary suggests that the differentiation and multiplication of certain epithelial cells cannot proceed in the absence of mesenchymal elements. She found that the isolated epithelial cells of the hypophysial rudiment survived but were unable to differentiate or multiply; when associated with perichondrial fibroblasts, however, they resumed mitosis and produced typical α and β cells. In the first part of the present investigation, experiments were made to see whether the embryonic epidermis, like the hypophysial epithelium, requires the resence of fibroblasts to enable it to grow and differentiate, or whether it can proliferate, acquire its characteristic squamous structure and keratinize, when isolated and cultivated in the absence of connective tissue.

Type: Article
Title: The importance of mesenchymal factors in the differentiation of chick epidermis I. the differentiation in culture of the isolated epidermis of the embryonic chick and its response to excess vitamin A
Publisher version: http://dev.biologists.org/content/9/3/370
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/1548799
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