Eikendal, ALM;
Groenewegen, KA;
Anderson, TJ;
Britton, AR;
Engstrom, G;
Evans, GW;
de Graaf, J;
... den Ruijter, HM; + view all
(2015)
Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged < 45 Years.
Hypertension
, 65
(4)
pp. 707-713.
10.1161/HYPERTENSIONAHA.114.04658.
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Abstract
Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavorable risk factor burden.
| Type: | Article |
|---|---|
| Title: | Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged < 45 Years |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1161/HYPERTENSIONAHA.114.04658 |
| Publisher version: | http://doi.org/10.1161/HYPERTENSIONAHA.114.04658 |
| Language: | English |
| Additional information: | Copyright © 2017 American Heart Association, Inc. All rights reserved. |
| Keywords: | Atherosclerosis, carotid intima-media thickness, risk factors, young adult, Adult, Cardiovascular Diseases, Carotid Intima-Media Thickness, Female, Follow-Up Studies, Humans, Incidence, Male, Netherlands, Prospective Studies, Risk Assessment, Risk Factors, Time Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1547598 |
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