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Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins

Cavodeassi, F; del Corral, RD; Campuzano, S; Dominguez, M; (1999) Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins. DEVELOPMENT , 126 (22) 4933 - 4942.

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Abstract

The Drosophila eye is patterned by a dorsal-ventral organising centre mechanistically similar to those in the fly sing and the vertebrate limb bud. Here we show how this organising centre in the eye is initiated - the first event in retinal patterning. Early in development the eye primordium is divided into dorsal and ventral compartments. The dorsally expressed homeodomain Iroquois genes are true selector genes for the dorsal compartment; their expression is regulated by Hedgehog and Wingless. The organising centre is then induced at the interface between the Iroquois-expressing and nonexpressing cells at the eye midline. It was previously thought that the eye develops by a mechanism distinct from that operating in other imaginal discs, but our work establishes the importance of lineage compartments in the eye and thus supports their global role as fundamental units of patterning.

Type: Article
Title: Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins
Keywords: Drosophila melanogaster, compartment, eye development, Iroquois proteins, dorsal-ventral patterning, MORPHOGENETIC FURROW, WING DEVELOPMENT, VENTRAL CELLS, EXPRESSION, DORSAL, HEDGEHOG, DIFFERENTIATION, RETINA, GENE, INITIATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/154664
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