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Zebrafish sleep: from geneZZZ to neuronZZZ

Barlow, IL; Rihel, J; (2017) Zebrafish sleep: from geneZZZ to neuronZZZ. Current Opinion in Neurobiology , 44 pp. 65-71. 10.1016/j.conb.2017.02.009. Green open access

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Abstract

All animals have a fundamental and unavoidable requirement for rest, yet we still do not fully understand the processes that initiate, maintain, and regulate sleep. The larval zebrafish is an optically translucent, genetically tractable model organism that exhibits sleep states regulated by conserved sleep circuits, thereby offering a unique system for investigating the genetic and neural control of sleep. Recent studies using high throughput monitoring of larval sleep/wake behaviour have unearthed novel modulators involved in regulating arousal and have provided new mechanistic insights into the role of established sleep/wake modulators. In addition, the application of computational tools to large behavioural datasets has allowed for the identification of neuroactive compounds that alleviate sleep symptoms associated with genetic neurological disorders.

Type: Article
Title: Zebrafish sleep: from geneZZZ to neuronZZZ
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.conb.2017.02.009
Publisher version: http://doi.org/10.1016/j.conb.2017.02.009
Language: English
Additional information: © 2017 Elsevier Ltd. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1546213
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