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Apparatus for histological validation of in vivo and ex vivo magnetic resonance imaging of the human prostate

Bourne, RM; Bailey, CEM; Johnston, EW; Pye, H; Heavey, S; Whitaker, H; Siow, B; ... Panagiotaki, E; + view all (2017) Apparatus for histological validation of in vivo and ex vivo magnetic resonance imaging of the human prostate. Frontiers in Oncology , 7 , Article 47. 10.3389/fonc.2017.00047. Green open access

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Abstract

This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patientspecific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution ex vivo imaging aids in registration of in vivo MRI and histopathology data.

Type: Article
Title: Apparatus for histological validation of in vivo and ex vivo magnetic resonance imaging of the human prostate
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fonc.2017.00047
Publisher version: http://dx.doi.org/10.3389/fonc.2017.00047
Language: English
Additional information: © 2017 Bourne, Bailey, Johnston, Pye, Heavey, Whitaker, Siow, Freeman, Shaw, Sridhar, Mertzanidou, Hawkes, Alexander, Punwani and Panagiotaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Prostate, prostate cancer, MRI validation, in vivo MRI, ex vivo MRI, histology, co-registration, fixation
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/1546165
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