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Cultural factors that affected the spatial and temporal epidemiology of kuru

Whitfield, JT; Pako, WH; Collinge, J; Alpers, MP; (2017) Cultural factors that affected the spatial and temporal epidemiology of kuru. ROYAL SOCIETY OPEN SCIENCE , 4 , Article 160789. 10.1098/rsos.160789. Green open access

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Abstract

Kuru is a prion disease which became epidemic among the Fore and surrounding linguistic groups in Papua New Guinea, peaking in the late 1950s. It was transmitted during the transumption (endocannibalism) of dead family members at mortuary feasts. In this study, we aimed to explain the historical spread and the changing epidemiological patterns of kuru by analysing factors that affected its transmission. We also examined what cultural group principally determined a family's behaviour during mortuary rituals. Our investigations showed that differences in mortuary practices were responsible for the initial pattern of the spread of kuru and the ultimate shape of the epidemic, and for subsequent spatio-temporal differences in the epidemiology of kuru. Before transumption stopped altogether, the South Fore continued to eat the bodies of those who had died of kuru, whereas other linguistic groups, sooner or later, stopped doing so. The linguistic group was the primary cultural group that determined behaviour but at linguistic boundaries the neighbouring group's cultural practices were often adopted. The epidemiological changes were not explained by genetic differences, but genetic studies led to an understanding of genetic susceptibility to kuru and the selection pressure imposed by kuru, and provided new insights into human history and evolution.

Type: Article
Title: Cultural factors that affected the spatial and temporal epidemiology of kuru
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsos.160789
Publisher version: http://dx.doi.org/10.1098/rsos.160789
Language: English
Additional information: © 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, epidemiology, cannibalism, transumption, kuru, prion, mortuary rites, CREUTZFELDT-JAKOB-DISEASE, PRION PROTEIN, VARIANT, TRANSMISSION, CANNIBALISM, PATTERNS, FORE
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/1546066
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