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Annexins and endocytosis

Futter, CE; White, IJ; (2007) Annexins and endocytosis. TRAFFIC , 8 (8) 951 - 958.

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Abstract

Annexins are calcium- and phospholipid-binding proteins that have been proposed to have multiple roles in membrane traffic. Historically, this has been based on the in vitro properties of annexins and their localization to specific membrane compartments. However, recent functional evidence supports a role for annexins in specific membrane traffic steps, although the requirement for annexins may be highly dependent on the cellular context. Here we review the roles of annexins in traffic within the endocytic pathway, focusing on clathrin-dependent internalization from the plasma membrane, multivesicular endosome/body (MVB) biogenesis and MVB-lysosome fusion.

Type:Article
Title:Annexins and endocytosis
Keywords:annexin, clathrin, lysosome, multivesicular body, GROWTH-FACTOR RECEPTOR, CLATHRIN-COATED PITS, MULTIVESICULAR BODY, MEMBRANE-BINDING, EARLY ENDOSOMES, ACTIN, VI, PROTEIN, VESICLES, COMPLEX

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