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Structural and Functional Brain Network Correlates of Depressive Symptoms in Premanifest Huntington’s Disease

Tabrizi, SJ; McColgan, P; Gregory, S; Seunarine, K; Durr, A; Raymund, R; Leavitt, B; (2017) Structural and Functional Brain Network Correlates of Depressive Symptoms in Premanifest Huntington’s Disease. Human Brain Mapping 10.1002/hbm.23527. (In press). Green open access

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Abstract

Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD.

Type: Article
Title: Structural and Functional Brain Network Correlates of Depressive Symptoms in Premanifest Huntington’s Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hbm.23527
Publisher version: http://dx.doi.org/10.1002/hbm.23527
Language: English
Additional information: © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Huntington’s disease; brain network; depression; functional MRI; diffusion tractography
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1545276
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