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Mitochondrial Function and Cell Size: An Allometric Relationship

Miettinen, TP; Björklund, M; (2017) Mitochondrial Function and Cell Size: An Allometric Relationship. Trends in Cell Biology 10.1016/j.tcb.2017.02.006. (In press).

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Abstract

Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.

Type: Article
Title: Mitochondrial Function and Cell Size: An Allometric Relationship
Location: England
DOI: 10.1016/j.tcb.2017.02.006
Publisher version: http://doi.org/10.1016/j.tcb.2017.02.006
Language: English
Additional information: © 2017 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1545238
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