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Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017.

Harvala, H; Frampton, D; Grant, P; Raffle, J; Ferns, RB; Kozlakidis, Z; Kellam, P; ... ICONIC Consortium, ; + view all (2017) Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017. Eurosurveillance , 22 (8) 10.2807/1560-7917.ES.2017.22.8.30466. Green open access

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Abstract

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

Type: Article
Title: Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017.
Location: Sweden
Open access status: An open access version is available from UCL Discovery
DOI: 10.2807/1560-7917.ES.2017.22.8.30466
Publisher version: http://dx.doi.org/10.2807/1560-7917.ES.2017.22.8.3...
Language: English
Additional information: This article is copyright of the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
Keywords: Influenza, molecular, next generation sequencing, outbreak
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: http://discovery.ucl.ac.uk/id/eprint/1544877
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