Kang, J and Macmillan, D (2010) Peptide and protein thioester synthesis via N -> S acyl transfer. ORG BIOMOL CHEM , 8 (9) 1993 - 2002. 10.1039/b925075a.
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Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In this Emerging Area we highlight recent developments in a somewhat surprising route to thioesters: selective disruption of amides, the more stable carboxylic acid derivatives.
|Title:||Peptide and protein thioester synthesis via N -> S acyl transfer|
|Keywords:||NATIVE CHEMICAL LIGATION, SOLID-PHASE SYNTHESIS, CPE AUTOACTIVATING UNIT, C-TERMINAL THIOESTERS, SHIFT REACTION, SPLIT INTEINS, ASSISTED THIOESTERIFICATION, GLYCOPEPTIDE THIOESTERS, AUXILIARY GROUP, CYSTEINE|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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