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Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle

Tedesco, FS; Moyle, LA; Perdiguero, E; (2017) Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle. In: Perdiguero, E and Cornelison, DDW, (eds.) Muscle Stem Cells: Methods and Protocols (Part III). (pp. 129-147). Springer New York: New York, USA. Green open access

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Abstract

Skeletal muscle regeneration is mainly enabled by a population of adult stem cells known as satellite cells. Satellite cells have been shown to be indispensable for adult skeletal muscle repair and regeneration. In the last two decades, other stem/progenitor cell populations resident in the skeletal muscle interstitium have been identified as "collaborators" of satellite cells during regeneration. They also appear to have a key role in replacing skeletal muscle with adipose, fibrous, or bone tissue in pathological conditions. Here, we review the role and known functions of these different interstitial skeletal muscle cell types and discuss their role in skeletal muscle tissue homeostasis, regeneration, and disease, including their therapeutic potential for cell transplantation protocols.

Type: Book chapter
Title: Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle
Location: United States
ISBN-13: 9781493967698
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4939-6771-1_7
Publisher version: http://dx.doi.org/10.1007/978-1-4939-6771-1_7
Language: English
Additional information: Copyright © 2017 Springer Science+Business Media LLC. The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4939-6771-1_7.
Keywords: Fibro-adipogenic progenitors, Interstitial cells, Mesenchymal progenitors, Mesoangioblasts, Muscle regeneration, Pericytes, Pw1, Skeletal muscle, Stem cells
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1544387
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