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Erythropoietin: ready for prime-time cardioprotection

Riksen, NP; Hausenloy, DJ; Yellon, DM; (2008) Erythropoietin: ready for prime-time cardioprotection. TRENDS PHARMACOL SCI , 29 (5) 258 - 267. 10.1016/j.tips.2008.02.002.

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Abstract

To improve clinical outcomes in patients presenting with an acute myocardial infarction, new strategies to limit infarct size and postinfarct remodelling are warranted. Recent animal studies have revealed that erythropoietin has the potential to achieve both these goals. Even more intriguing is the possibility that erythropoietin could protect the myocardium when administered well after the onset of reperfusion. In this article we review the evidence in favour of erythropoietin-induced cardioprotection and the proposed underlying mechanisms. Inhibition of apoptosis and inflammation, as well as stimulation of neovascularization, all could contribute to cardioprotection. Activation of the reperfusion injury salvage kinase pathway at the moment of reperfusion appears to be a pivotal mechanism in the infarct size-limiting effect. Now that recent evidence has proven that erythropoietin also can protect the human heart, studies currently are being undertaken to examine the effect of administration of erythropoietin in patients presenting with an acute myocardial infarction.

Type: Article
Title: Erythropoietin: ready for prime-time cardioprotection
DOI: 10.1016/j.tips.2008.02.002
Keywords: ISCHEMIA-REPERFUSION INJURY, ACUTE MYOCARDIAL-INFARCTION, IMPROVES CARDIAC-FUNCTION, GLYCOGEN-SYNTHASE KINASE-3-BETA, PERMEABILITY TRANSITION PORE, ENDOTHELIAL PROGENITOR-CELL, CHRONIC HEART-FAILURE, DARBEPOETIN-ALPHA, INFLAMMATORY RESPONSE, DOUBLE-BLIND
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/154420
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