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Relation of myocardial T2* to right ventricular function in thalassaemia major

Alpendurada, F; Carpenter, JP; Deac, M; Kirk, P; Walker, JM; Porter, JB; Banya, W; ... Pennell, DJ; + view all (2010) Relation of myocardial T2* to right ventricular function in thalassaemia major. European Heart Journal , 31 (13) pp. 1648-1654. 10.1093/eurheartj/ehq106.

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Abstract

Aims Myocardial T2* cardiovascular magnetic resonance (CMR) provides a rapid and reproducible measure of cardiac iron loading and is being increasingly used worldwide for monitoring of transfusion-dependent thalassaemia patients. Although myocardial siderosis (T2* <20 ms) is associated with impaired left ventricular (LV) function, little is known of its relation with right ventricular (RV) function. The aim of this study was to investigate the relationship between cardiac T2* and RV function. Methods and results A retrospective analysis of 319 patients with beta-thalassaemia major presenting for their first CMR scan was performed (45.1 male, mean age 25.6 years). In patients with normal myocardial T2* (>20 ms), the RV ejection fraction (EF) was within the normal range in 98 of patients. When myocardial T2* was <20 ms, there was a progressive and significant decline in RV EF. There was a linear relationship between RV and LV EF. Conclusion Myocardial iron deposition is strongly associated with RV dysfunction, which mirrors the decrease in LV function seen with worsening cardiac iron loading. Right ventricular dysfunction may play a significant role in heart failure associated with myocardial siderosis. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010.

Type: Article
Title: Relation of myocardial T2* to right ventricular function in thalassaemia major
DOI: 10.1093/eurheartj/ehq106
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/1543531
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